In “Reigniting Malaysia’s Nuclear Ambition: From Hesitation to Regional Leadership,” Ikhwan Khaleb argues that Malaysia’s unrealised nuclear aspirations represent a missed strategic opportunity at a time of surging energy demand and urgent decarbonisation needs in Southeast Asia. Despite early leadership in nuclear science and renewed regional momentum toward nuclear power, Malaysia remains stalled in the consideration phase, constrained by policy gaps, institutional inertia, and lingering public scepticism. The article contends that nuclear energy is not merely an optional supplement to renewables but a necessary, stable, and low-carbon backbone for achieving net-zero goals and energy security. Reflecting on Malaysia’s 2025 ASEAN Chairmanship, Khaleb calls for decisive action through robust regulatory frameworks, accelerated institutional readiness, strategic talent development, innovative financing, and sustained public engagement. Drawing parallels with national success stories such as PETRONAS and Penang’s semiconductor ecosystem, the piece concludes that with clear policy direction, coordinated execution, and public trust, nuclear power could become a defining pillar of Malaysia’s return to scientific leadership and a catalyst for regional energy sovereignty.